PDF | Libidibia ferrea, popularly known as “pau ferro” or “jucá”, is an important medicinal plant employed for the treatment of various ailments in. Genus: Libidibia (formerly known as Ceasalpinia). species: ferrea. Family: Fabaceae. Common Name: Leopard tree, Brazilian Ironwood. Description. Unarmed tree, to 15 m. Bark very distinctive, smooth, grey, pealing to reveal paler patches. Leaves 2-pinnate; pinnae in pairs, each with

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Libidibia ferrea

Carneiro-da-Cunha1 T. It is found along all tropical regions in Brazil but manly in the north and northeast areas [ 1 ]. Pau ferro, used as a rosewood substitute, is a strong sensitizer capable of causing acute outbreaks of allergic and irritant dermatitis in workers not previously exposed to it. Cells were counted with an inverted LEITZ microscope and a hemocytometer filled with a homogeneous cell suspension aliquot. The negative control group lubidibia given saline, always in the same route of administration as the drug.

BioMed Research International

Since anti-inflammatory drugs decrease the concentration of PGE 2which is responsible for activating and lowering the excitatory threshold of peripheral polimodal nociceptive neurons, anti-inflammatory drugs can cause a secondary analgesic effect. This seems to be common in this genus since Caesalpinia sappan [ 18 ] and Caesalpinia echinata [ 19 ] also have linoleic acid as their main fatty acid component with Antitumor Activity Studies were carried out in male mice, six animals per group, aiming to investigate the in vivo antitumor activity of CE and F80 against sarcoma In addition to the well-known peripheral effects of NSAIDs—especially prostaglandin synthesis inhibition—and the fact that dipyrone is able to induce a significant antinociceptive effect in the absence of an anti-inflammatory response, it has been proposed that it produces antinociception at least partially by acting upon central nervous system structures [ 4344 ].

Although this assay is nonspecific e. Protocols for screening chemical agents and natural-products against tumors and other biological systems. On the other hand, their low toxicity allows the use of CE and F80 with a degree of safety in other situations. It suggests that LF compounds could be promoting the antinociceptive effect in A-delta fibers.


The time necessary for the initial response to the painful stimulus taping of the paws, licking or jumping was taken as defining nociceptive response. Effects of the standard drugs, piroxicam and dipyrone, CE, and F80 in relation to the control group on writhing induced in mice by intraperitoneal injection of acetic acid.

The hot-plate test was used to measure the response latencies according to the method described previously [ 12 ]. Previous Melbourne Royal Botanic Gardens.

Queiroz Leguminosaewhose basionym is Caesalpinia ferrea Mart. Several previous studies have demonstrated that plant extracts and derivative compounds have an anticancer potential in vitro or in vivo. Antinociception induced by PAG-microinjected libidibla metamizol in rats: Animal experiments were performed ljbidibia to the NCI protocol [ 13 ].

View at Google Scholar M. Thus, in the present study, we identified the main storage substances and their accumulation sites in Libidibia ferrea seeds, identified its main lipid components, and investigated the analgesic effect of LF on chemical and thermal models of nociception in mice and its possible mechanism of action. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. The present study utilized the following drugs: Leaves 2-pinnate; pinnae in pairs, each with pairs of oblong, asymmetric leaflets.

Thus, suppression of iNOS is closely linked with anti-inflammatory action [ 32 ]. Evaluation of anti-inflammatory activity of standard drugs dexamethasone, piroxicam and indomethacinCE, and F80 on carrageenan-induced peritonitis in pretreated mice. As previous data show Libidibia ferrea seed causes inhibition on neurogenic pain and to confirm this form of antinociception, a hot-plate test was performed. Histochemical tests in the longitudinal section of seeds of Libidibia ferrea.

It can also be used as a pioneer plant for its native woodland because of its tolerance to sun, reasonably fast growing and nitrogen fixing ability. Control wells received only 0.

Antinociceptive action demonstrated in the present study cerrea, at least partly, the ethnomedical uses of this plant and complements previous studies of this plant. Hot-Plate Test The hot-plate test was used to measure the response latencies according to the method described previously [ 12 ]. View at Google Scholar R. Libidibia ferreaformerly Caesalpinia ferrea[1] [2] and commonly known as Pau FerroBrazilian ironwoodMoradoor leopard tree[3] is a tree found in Brazil and Bolivia. European Journal of Pharmacology.


Subsequently, it suggests that prostaglandin biosynthesis might be commonly involved in both activities of CE and F80 or that the mode of action of both preparations is related to sensitization of nociceptive receptors to prostaglandins.

Libidibia ferrea

Additionally, findings in Nile libidbiia sulphate test possibly confirm the presence of the triacylglycerols in the oily bodies Figures 2 g and 2 h. Studies on libodibia reductase system—III. Their flowers fall as well as their hard black seed pods which can cause trip hazards on paths and cause injury if pods are run over by mower blades.

A concentration of 6. Libidibia ferrea LF is a medicinal plant that holds many pharmacological properties.

Biochemical and Biophysical Research Communications. Then, acetone was added and the solution was incubated at one week. MTT assay is based on the capability of living cells to reduce yellow tetrazolium salt into insoluble, purple formazan [ 11 ] which precipitates due libiribia the mitochondrial enzyme succinate dehydrogenase active in living cells [ 12 ].

The strong reduction by CE of nitrite level in the exudate might be attributed to the presence of antioxidant compounds in this aqueous extract. Coelho1 M. Osmium tetroxide test revealed that most of the totality of lipids observed was mainly unsaturated and predominantly observed in the cotyledon Figure 2 din the macrosclereids, and in the thicker cell walls of the fibers Figures 2 e – 2 f. The extract and fraction were evaluated following the steps of Guideline [ 14 ] using female mice.

Animals 6 per group were pretreated by i. In the analyses, linoleic acid One hour later, a dose of 0. Several reports support a role for acetylcholine ACh in the inhibition and modulation of the transmission of nociceptive information [ 3839 ].