Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Amaç: İdiopatik trombositopenik purpura (ITP); trombositopenî, trombosit ömründe kısalma, plazmada anti-trombosit antikorların varlığı ve kemik iliğinde. Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal.

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Other immunosuppresants, which are steroid sparing drugs like mycophenolate mofetil and azathioprine, are becoming more popular for their effectiveness.

Idiopathic thrombocytopenic purpura

ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens. The diagnosis of ITP is a diagnosis of exclusion. Intravenous immunoglobulin IVIg may be infused in some cases in order to decrease the rate at which idiopstik consume antibody -tagged platelets. Idiopathic thrombocytopenic purpura ITP is defined trombosti a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause.

The evolution of drug discovery: In chronic refractory cases, where immune pathogenesis has been confirmed, [15] the off-label use of the vinca alkaloid [16] [17] [18] and chemotherapy agent vincristine may be attempted. Coagulopathies Vascular-related cutaneous conditions Idiopathic diseases Rare diseases.

Journal List Contemp Clin Dent v. In a study conducted in Great Britainit was noted that ITP causes an approximately 60 percent higher rate of mortality compared to gender- and age-matched subjects without ITP. With rare exceptions, there is usually no need to treat based on platelet counts. Adults are usually started on a idiopatok medicine called prednisone. This increased risk of death with ITP is largely concentrated in the middle-aged and elderly.


The major goal for treatment of ITP is to provide a safe platelet count to prevent major bleeding and avoid unnecessary treatment of asymptomatic patients with mild to moderate thrombocytopenia.

There is no accepted platelet count that defines an indication for initial treatment. National Center for Biotechnology InformationU. Urea breath testing and stool antigen testing perform better than serology -based tests; moreover, serology may be false-positive after treatment with IVIG.

Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. Introduction Idiopathic thrombocytopenic purpura ITP is the condition of having a low platelet count thrombocytopenia of no trombositt cause idiopathic.

Bleeding time from minor lacerations or abrasions is usually prolonged. ITP is usually chronic in adults [40] and the probability of durable remission is 20—40 percent.

Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia

Platelets were unknown at the time. Such secondary causes include leukemiamedications e. Not to be confused with autoimmune thrombotic thrombocytopenic purpura. The procedure is potentially risky in ITP cases due to the increased possibility of significant bleeding during surgery. Blood tests will be tormbosit to check your platelet count. Uncommon findings are gastrointestinal GI bleeding, gross hematuria and intracranial hemorrhage.

Immune thrombocytopenic purpura

Immune thrombocytopenic purpura – From agony to agonist. Goldman L, Schafer AI, eds. Diagnosis and treatment of idiopathic thrombocytopenic purpura: An exception to this rule is when a patient is bleeding profusely, when transfusion of platelets can quickly form a platelet plug to stop bleeding.


The treatment begins with IV steroids methylprednisolone or prednisoneIVIg or their combination and sometimes platelet infusions in order to raise the count quickly. When to Contact a Medical Professional.

Idiopathic thrombocytopenic purpura

Dapsone for chronic autoimmune thrombocytopenic purpura: In adults, particularly those living in areas with a high prevalence of Helicobacter pylori which normally inhabits the stomach wall and has been associated with peptic ulcersidentification and treatment of this infection has been shown to improve platelet counts in a third of patients.

Petechia, purpura, and easy bruising are expected in ITP.

Children should be discouraged from rough contact sports or other activities that increase the risk of trauma. Go to the emergency room or call the local emergency number such as if severe bleeding occurs, or if other new symptoms develop.

Trkmbosit thrombocytopenic purpura ITP is the condition of having a low platelet count thrombocytopenia of no known cause idiopathic. Epidermal wart callus seborrheic keratosis acrochordon molluscum contagiosum actinic keratosis squamous-cell carcinoma basal-cell carcinoma Merkel-cell carcinoma nevus sebaceous trichoepithelioma.

Views Read Edit View history. We present a case report on ITP with clinical tromboskt, diagnosis and management. The mechanism of action of anti-D is not fully understood.