Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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Moderate CYP3A4 inhibitors, like ranolazine, may reduce the metabolism of diazepam and increase the potential for benzodiazepine toxicity. Moderate Due to the CNS effects of lurasidone, caution should be used when lurasidone is given in combination with other centrally acting medications such as anxiolytics, sedatives, and hypnotics, including benzodiazepines.
If an opiate agonist is initiated in a patient taking a benzodiazepine, use a lower initial dose of the opiate and titrate to clinical response.
Moderate Pregabalin can potentiate the CNS-depressant action of other drugs such as benzodiazepines. Moderate Coadministration of diazepam and digoxin has been reported to increase the half-life of digoxin due to reduced urinary excretion of digoxin. Turn person on side facing you and bend upper leg forward to expose rectum. Patients on benzodiazepine therapy should avoid concomitant administration of kava kava.
Single doses of 2 to 5 mg IV or PO have been recommended. If a cracked syringe is noted, notify your dispensing pharmacist to inspect the product. Moderate Patients taking benzodiazepines with perampanel may experience increased CNS depression. Small cracks have been noted at the base of the plastic tip of the applicators with resultant leakage informatino the medication when the plunger is depressed, preventing full dosing and potentially resulting in a sub-optimal therapeutic response.
Diazepam is a substrate of CYP3A4.
Diastat® AcuDial™: Breakthrough Seizure Control
Co-administration with nicardipine may lead to an increase in serum levels of drugs that are CYP3A4 substrates including diazepam. Iformation a benzodiazepine is prescribed for an prescdibing other than epilepsy in a patient taking an opiate agonist, use a lower initial dose of the benzodiazepine and titrate to clinical response. Patients taking medications such as tricyclic antidepressants, lithium, MAOIs, skeletal muscle relaxants, SSRIs and serotonin norepinephrine reuptake inhibitors e.
If used together, a reduction in the dose of one or both drugs may be needed. There are exceptions that may warrant the use of an anxiolytic such as a long-acting benzodiazepine for withdrawal from a short-acting benzodiazepine, use for neuromuscular syndromes e.
Coadministration of etravirine and diazepam, a CYP2C19 substrate, may result in increased diazepam plasma concentrations. Moderate Concomitant administration of benzodiazepines with CNS-depressant drugs, such as tricyclic antidepressants, can potentiate the CNS effects of either agent.
The mechanistic rational for this contraindication has been questioned, as benzodiazepines do not have antimuscarinic activity and do not raise intraocular pressure. Moderate In premarketing studies, zaleplon potentiated the CNS effects of ethanol, informatuon, and thioridazine for at least 2 to 4 hours. For extended-release tablets, start with morphine 15 mg PO every 12 hours, and for extended-release capsules, start with 30 mg PO every 24 hours or less.
Diazepam is not recommended for use in obstetrical procedures, labor, or obstetric delivery, including cesarean section. The effects of aprepitant on tolbutamide were not considered significant.
Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: The valerian derivative, dihydrovaltrate, binds at barbiturate binding sites; valerenic acid has been shown to inhibit enzyme-induced breakdown of GABA in the brain; the non-volatile monoterpenes valepotriates have sedative activity.
Major Droperidol administration is associated with an established risk for QT prolongation and torsades de pointes. The combined administration of citalopram with triazolam has not been reported to significantly affect the pharmacokinetics of either drug.
Moderate Concomitant use of nabilone with other CNS depressants can potentiate the effects of nabilone on respiratory depression. Moderate Coadministration of diazepam and valdecoxib may result in increased exposure to diazepam. A proposed mechanism is competitive binding of aminophylline to adenosine receptors in the brain.
Fosphenytoin should be used cautiously with clonazepam and diazepam, as decreased clonazepam or diazepam serum concentrations may be seen. The manufacturer recommends obtaining periodic liver function tests during chronic treatment due to rare reports of jaundice. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: CNS depression, coma, driving or operating machinery, ethanol intoxication, shock.
Dosage should be modified depending on clinical response and degree of hepatic impairment, but no quantitative recommendations are available.
Consider measuring serum digoxin concentrations before initiating diazepam. If an AcuDial ihformation was used, pull the plunger out and then replace and push in to expel any remaining drug into the sink or toilet. In vitro, the metabolism of paclitaxel is inhibited by diazepam but concentrations used exceeded those found in vivo following normal therapeutic doses.
Aluminum Hydroxide; Magnesium Hydroxide: Moderate Concomitant administration of benzodiazepines with CNS-depressant drugs, including opiate agonists, can potentiate the CNS effects of either agent. A reduction in dose of the CNS depressant may be needed in some cases.
Initially, 1 to 2. Major Coadministration of marijuana with benzodiazepines may result in an exaggerated sedative effect. Moderate Use caution if coadministration of telotristat ethyl and diazepam is necessary, as the systemic exposure diashat diazepam may be decreased resulting in reduced efficacy. Dilution may cause precipitation. Drugs that can cause CNS depression, if used concomitantly with vigabatrin, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness.
In animal studies, melatonin has been shown to increase benzodiazepine binding to receptor sites. Infants and Children 6 months—5 years.
Diastat (diazepam) dose, indications, adverse effects, interactions from
Moderate Ziprasidone has the potential to impair cognitive and motor skills. Moderate Use caution when administering ivacaftor and diazepam concurrently because patients may be at increased risk for adverse effects from diazepam. Benzodiazepines may also have other actions.
If diasta dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment. Diazepam is partially metabolized by the hepatic isoenzyme CYP3A4; boceprevir inhibits this isoenzyme. Alcohol taken with other CNS depressants can lead to additive respiratory depression, hypotension, profound sedation, or coma. Monitor closely for signs of reduced diazepam effects. Grapefruit juice has been shown to increase diazepam peak serum concentrations Cmax and exposure AUC by 1.