DEFICIT DE ALFA 1 ANTITRIPSINA EN PEDIATRIA PDF

Neonatal hyperbilirubinemia is influenced by a wide variety of factors, one of which is hemolysis. Serious .. jaundice (BMJ), deficiency in UGT1A1 expression is a known cause of BMJ. . Copyright © Sociedade Brasileira de Pediatria. de alfaantitripsina 13,1%, sífilis 21,1 %, auto-anticorpos hepáticos 58,4%. Items 1 – 50 of In Apgar 1, the percentage of critical neonates, moderate viability neonates and The neonatal presentation of CLPB deficiency predicts the course of disease in Copyright © Sociedade Brasileira de Pediatria. 2,4%, toxoplasmose 2,8%, deficiência de alfaantitripsina 13,1%, sífilis 21,1 %. Request PDF on ResearchGate | On Sep 1, , M I Ubeda Sansano and Article in Anales espanoles de pediatria 45(2) · September with 1 Reads . Casos clínicos sobre déficit de alfa-1 antitripsina: EL DAAT VISTO DESDE.

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Directory of Open Access Journals Sweden. Full Text Available Hyperbilirubinemia is common in neonates ; it can have a serious rising course. Due to its critical morbidity called “kernicterus”, severe neonatal hyperbilirubinemia causes which lead to exchange transfusion, should be clarified. This descriptive cross sectional study performed with reviewing of files of neonates weighting 2kg and more who had exchange transfusion in pediatrics ward antitrpsina Ghaem training hospital in Mashhad from April to March Among patients, 75 alda The most common cause of exchange transfusion was ABO incompatibility In order of frequency, unknown etiology Vaginal delivery and exclusive breast feeding were detected as associated factors.

Mean serum bilirubin levels was ABO incompatibility was the main cause of exchange transfusion.

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Male gender, vaginal delivery defficit exclusive breast feeding were seen more among patients who deficut to be exchanged. So in case of ABO incompatibility especially when peviatria route is vaginal, newborns should be visited soon again after early discharge from hospital.

Hiperbilirrubinemia neonatal agravada Aggravated neonatal hyperbilirubinemia. La hiperbilirrubinemia neonatal agravada constituye un problema de salud. Los factores agravantes son anyitripsina prematuridad y el bajo peso al nacer. Most of times jaundice in newborn is a physiological fact due to hyperbilirubinemia of indirect predominance, secondary to liver immaturity and to bilirubin hyperproduction.

The aim of present of present study was to determine the behavior of neonatal hyperbilirubinemia in the Gynecology and Obstetrics Teaching Hospital of Guanabacoa municipality from to A retrospective and descriptive study was conducted in newborn patients admitted in the Neonatology Department diagnosed with severe hyperbilirubinemia. Efficacy of zinc sulfate in reducing unconjugated hyperbilirubinemia in neonates. Full Text Available Hyperbilirubinemia is dedicit common disease angitripsina unconjugated hyperbilirubinemia has been seen mainly in neonates.

Severe form of unconjugated hyperbilirubinemia may cause df and even death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion that have several known disadvantages; ce exchange transfusion is associated with a significant morbidity and even mortality. These harmful effects indicate the need to develop alternative pharmacological treatment strategies for unconjugated hyperbilirubinemia.

One of these pharmacological agents is zinc salts. Zinc has been shown to lower the bilirubin levels by inhibition of the enterohepatic cycling of unconjugated bilirubin. Oral zinc has been shown to reduce serum unconjugated bilirubin in animals, adolescents and low birth weight neonates. However, studies in healthy term neonates given oral zinc showed no reduction in hyperbilirubinemia based on daily measurement. In order to improve the accuracy, hyperbilirubinemia may be determined based on measurements every hour.

More studies are needed to know the effect of zinc in neonatal jaundice. Practice patterns in neonatal hyperbilirubinemia. To determine practice patterns of office-based pediatricians and neonatologists in the treatment of neonatal hyperbilirubinemia in healthy, term newborns duringbefore the publication of the practice guideline for treatment of neonatal jaundice by the American Academy of Pediatrics AAP.

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The survey was undertaken to inform the AAP’s Subcommittee on Hyperbilirubinemia on current practices and to aid it in its preparation of the guidelines. It was also anticipated that this survey would serve as a basis for comparison for a second survey to be performed several years after the publication of the practice guidelines.

A self-administered questionnaire describing a single case of a jaundiced, breastfed hour-old healthy, full-term infant with a total serum bilirubin concentration of Respondents were asked to answer questions regarding treatment of the case based on their actual practices.

Ranges of total serum bilirubin concentration were provided as possible answers to questions on initiation of phototherapy and exchange transfusion, and interruption of breastfeeding. Respondents were also queried about frequency of serum bilirubin testing, locations of phototherapy administration, and defifit influencing their therapeutic decisions.

Four hundred forty-two office-based pediatricians and neonatologists completed the survey. There was a tendency for neonatologists to initiate deifcit phototherapy and exchange transfusions at lower serum bilirubin concentrations than antitrjpsina general pediatricians.

Forty percent of office-based practitioners said they would perform exchange transfusions at serum bilirubin levels. In this article, the sensorineural hearing loss is presented as a possible sequelae of neonatal hyperbilirubinemia.

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In our program of early hipoacusia detection, babies were examined from January until November ; 7 cases had a history of hyperbilirubinemia in the neonatal period and 2 of them were diagnosed of sensorineural hearing loss. We discuss how the bilirubin or any other associated factor might have been the cause and this could explain the selective affectation of some children.

The relationship between neonatal hyperbilirubinemia and sensorineural hearing loss. Severe jaundice that requires exchange transfusion has become a relatively rare situation today. Hyperbilirubinemia at birth is a risk factor associated with hearing loss that is usually further linked to other factors that might have an effect on hearing synergistically.

This study aimed to identify the relationship between hyperbilirubinemia at birth as a risk factor for sensorineural hearing loss in children born at Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, in the period. This was a retrospective study of newborns that had hyperbilirubinemia at birth, using transient evoked otoacoustic emissions and evoked auditory brainstem response. Hundred eighty-five newborns Hearing loss was diagnosed for 35 4.

Half of the children had other risk factors associated, the most frequent being exposure to ototoxic medications. The percentage of children diagnosed with sensorineural hearing loss that suffered hyperbilirubinemia at birth is higher than for the general population. Effect of Bilineaster Drop on Neonatal Hyperbilirubinemia. Full Text Available Background: Hyperbilirubinemia is considered one of the most prevalent problems in newborns.

This study aimed to investigate the effect of bilineaster drop on neonatal hyperbilirubinemia. This study was a randomized clinical trial conducted on 98 term neonates aged days with neonatal jaundice admitted to Ghaem Hospital of Mashhad, Iran, during These newborns were randomly assigned into intervention phototherapy and bilineaster drop and control only phototherapy groups. Total and direct serum bilirubin levels were measured at the time of admission and then 12, 24, 36, and 48 h after treatment.

The mean ages of the newborns at the time of admission were 6. Nonetheless, bilirubin levels significantly diminished in both groups over time P. Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia. Neonatal hyperbilirubinemia is influenced by a wide variety of factors, one of which is hemolysis. Serious hyperbilirubinemia may lead to a kernicterus with detrimental neurologic sequelae. Patients suffering from hemolytic disease have a higher risk of developing kernicterus.

It is transported as carboxyhemoglobin COHb and exhaled through the lungs. We were interested in a potential correlation between COHb and total serum bilirubin TSB and the time course of both parameters. We used a point of care POC blood gas analyzer and did a retrospective analysis of bilirubin and COHb data collected over a day period. Full Text Available We report on a Filipino neonate with early onset and prolonged hyperbilirubinemia who was delivered by a vacuum extraction due to a prolonged labor.

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Subsequent studies revealed adrenal hemorrhage and glucosephosphate dehydrogenase G6PD deficiency. It is likely that asphyxia and resultant hypoxia underlie the occurrence of adrenal hemorrhage and the clinical manifestation of G6PD deficiency and that the presence of the two events explains the early onset and prolonged hyperbilirubinemia of this neonate.

Our results represent the importance of examining possible underlying factors for the development of severeearly onset, or prolonged hyperbilirubinemia. The introductory summarises the classical path of heme degradation and classification of jaundice. Special attention is given to a recently discovered molecular mechanism of the Rotor syndrome. The mechanism is based on the inability of the liver to retrospectively uptake the conjugated bilirubin fraction primarily excreted into the blood, not bile.

A reduced ability of the liver to uptake the conjugated bilirubin contributes to the development of hyperbilirubinemia in common disorders of the liver and bile ducts and to the toxicity of xenobiotics and drugs using transport proteins for conjugated bilirubin. Effect of oral zinc on hyperbilirubinemia in full term neonates. Full Text Available Background Oral zinc has been shown to reduce serum unconjugated bilirubin in animals, adolescents and low birth weight neonates.

However, studies in healthy tenn neonates given oral zinc showed no reduction in hyperbilirubinemia based on time measurement in days. In order to improve accuracy, hyperbilirubinemia may be determined based on time measurements in hours.

Objective To determine the effect of oral zinc on hyperbiliru-binemia in full term neonatesbased on time measurement in hours, rather than days. Methods We conducted a randomized, double-blind clinical trial on healthy term neonates born spontaneously or through elective caesarean section in Hasan Sadikin Hospital from June to July Subjects were randomized into two groups: Serum total bilirubin level was examined at discharge and upon followup at day 5 of life.

Factors which may be related to hyperbilirubinemia such as maternal age, infants’ gender, umbilical cord bilirubin levels and type of feeding, were analyzed by Chi-square test. Hyperbilirubinemia persistence and comparison of survival distributions were analyzed by Kaplan-Meier survival analysis and Logrank test. Results Out of 60 subjects, 26 had hyperbilirubinemia.

The mean duration of hyperbilirubinemia in the 15 subjects in the zinc group and 11 in the placebo group were Conclusions Oral zinc 5 mg tMce daily made no significant difference in hyperbilirubinemia duration in full tenn neonates despite measuring in hours.

Role of Saccharomyces boulardii in Reduction of Neonatal Hyperbilirubinemia. Probiotics are known to reduce the 11 of hyperbilirubinemia.

deficit alfa 1 antitripsina pediatria pdf

This study was done to evaluate the effect of probiotic on neonatal hyperbilirubinemia in term neonates. A total of two doses were given orally in the first two consecutive defkcit. The serum bilirubin levels were detected on day three of life. Babies were exclusively breastfed, clinical outcome was recorded. Comparison between groups was made by the non-parametric Mann-Whitney test.

A p-value of jaundice is 6. In patient with clinical jaundice, it is The p-value was found to be Probiotics lowered the serum bilirubin level of healthy neonate with jaundice safely and significantly without any adverse reaction.