Download scientific diagram | – Cnidoscolus quercifolius plant. from publication: Análise Química e Bromatológica da Forragem da Faveleira (Cnidoscolus. PDF | Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential. The Cnidoscolus quercifolius (Pohl) popularly known as “favela” or “faveleira” is a forager that is part of the native species from the caatinga.

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Among quefcifolius is the faveleiraused in northeastern Brazil. Chemical tests were performed using specific reagents, observing color changes or formation of precipitate, characteristic for each class of substances. Despite the negative presence of alkaloids in the faveleira extracts tested, the plant presented satisfactory activity of enzyme inhibition, when compared with the reference substance, raising the querciifolius that new untested substances may act on the inhibition of AChE.

In many cases, the procedures of modern medicine and popular medicine are supplemental and constitute an effective form of primary health care, which may supplement the treatment usually employed in the lower income population. In performing the inhibition test of fungal growth, it was observed that the LME showed inhibition against Lasiodiplodia theobromae LF11, L.

The quercifokius vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF, HCT, HL strains and the samples were assessed by 3- 4,5-dimethylthiazol2-yl -2,5-diphenyltetrazolium bromide method. Almeida [ 43 ] queecifolius an antimicrobial assay with strains of bacteria and fungi using hydroalcoholic extract of the leaves of C. The halos were measured and compared with the halo formed by physostigmine, a standard alkaloid.

Cnidoscolus quercifolius – Wikipedia

The World Health Organization WHO has recognized and recommended the dissemination of traditional knowledge and use of phytotherapic medicines. Preliminary Phytochemical Analysis The extracts were subjected to phytochemical quercifollius, following the protocols described by Mattos [ 16 ].

It stands out for its extraordinary drought resistance and cnidosclous properties. Materials and Methods 2. For this reason, the present study focuses on the assessment of the quercfiolius potential of this plant, by investigating its possible antioxidant, antimicrobial, and inhibitory activity of the acetylcholinesterase enzyme AChEas well as the toxicity of the methanolic extracts from three parts of Cnidoscolus quercifolius Pohl. The semiarid region of the Brazilian Northeast is known for hosting a number of native species that are under systematic exploitation in recent years, without any sustainable management, which ultimately causes the extinction of some species, thus unleashing a rural exodus.


The cnidoscolys of nuclear magnetic spectra of the active chloroform fraction revealed the presence of absorptions bands correspondent to a mixture of favelines such as neofavelanone, deoxofaveline or methyl-faveline, which structures were confirmed by ultraviolet spectra upon high-performance liquid chromatography with diode-array detection analysis.

Subscribe to Table of Contents Alerts. All the methanolic extracts of the faveleira presented anticholinesterase activity.

Cnidoscolus quercifolius

Antimicrobial assays against bacterial strains and fungi tested, using commercial drugs Chloramphenicol, Streptomycin, and Thiabendazole as a positive control, showed no growth of microorganisms. Thus, the antioxidant therapies used in a large number of illnesses related to the generation of free radicals, such as cancer, aging, atherosclerosis, ischemia, inflammation, and neurodegenerative diseases, seem to be promising [ 35 ]. De Almeida Alves, A. Antimicrobial activity of the methanolic extracts of C.

Today, according to Amorozo [ 2 ], the introduction of modern medicine offers another option for health practices in traditional communities that use popular medicine.

Most studies on the faveleira are targeted at its use in the agricultural and livestock fields, and very few studies of the species focus on the area of chemistry of natural products and biological activity. In the present study, the methanolic extracts of the leaf, root, and root bark of C.

The improvement of the conditions of oxidative stress by plants has been associated with phenolic compounds such as flavonoids and other polyphenols. Result of inhibition of the acetylcholinesterase enzyme from methanolic extracts of C. Assays were performed in triplicate, and the number of dead larvae was counted after 24 hours. Antioxidant Activity The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, as quercifollius reported by Brand-Williams et al.


Man has long been using plants to promote health, in the belief that they carry beneficial substances for a healthy existence. Moreover, other factors such as seasonality, circadian rhythm, development, climatic factors, water availability, ultraviolet radiation, nutrients, air pollution, and altitude may influence the composition of the secondary metabolites of plants [ 32 ].

This difference in the presence and absence of certain chemical compounds of plant species may be related to factors such as age of the plant and the time of collection [ 31 ]. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any quercivolius, provided the original work is properly cited. Standing out among these auspicious outcomes are the antioxidant effects, the bactericidal and fungicidal potential, and the inhibitory effect against the acetylcholinesterase enzyme in two extracts tested, which showed no significant difference when compared with the reference drug.

The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, as previously reported vnidoscolus Brand-Williams et al. The determination of the Minimum Inhibitory Concentration of Fungi MIC-f was obtained with a stereoscope, verifying the lower concentration of samples capable of inhibiting the growth of the microorganism, after 5 days of incubation.

Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl

To determine the biological activities the authors conducted investigation of antioxidant and antimicrobial activities, inhibition capacity of the acetylcholinesterase enzyme, and initial assessment of toxicity of the extracts.

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