BYETTA PI PDF

Learn about BYETTA, the BYETTA Pen. Important Safety Information for BYETTA (exenatide) injection. Contraindications. BYETTA is contraindicated in. Exenatide (Byetta) is the first in a new class of incretin peptide mimetics .. Available at ; accessed October 15, 3. Meneilly. Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) medication, belonging to the group of incretin.

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Pen-sharing poses a buetta for transmission of blood-borne pathogens, even if the needle is changed. Section 3 Now that you have done the one-time-only new pen setup, follow Section byettta for all of your injections. Aaron BondPharmD. A small drop of liquid may appear. Oftentimes patients with diabetes have gastroparesis, and exenatide may compound this disease complication, but more studies are forthcoming. See “What is the most important information I should know about Byetta?

Pharmacokinetics of exenatide was studied in subjects with normal, mild, or moderate renal impairment and subjects with end-stage renal disease.

Tell your healthcare provider if you are pregnant or plan to become pregnant.

Because Byetta is commonly associated with gastrointestinal adverse reactions, including nausea, vomiting, and diarrhea, the use of Byetta is not recommended in patients with severe gastrointestinal disease. Byetta slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

No data are available on the safety or efficacy of intravenous or intramuscular injection of Byetta. DeFronzo et al compared exenatide in type 2 diabetic patients being treated byettaa metformin byetra in a multi-centered, randomized, triple-blinded, placebo-controlled study 6. August 26, ; accessed August 28, Patients should be instructed btetta promptly discontinue Byetta and contact their physician if persistent severe abdominal pain occurs [see Warnings and Precautions 5.

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One of the three patients experienced severe hypoglycemia requiring parenteral glucose administration. Exenatide was not mutagenic or clastogenic, with or without metabolic activation, in the Ames bacterial mutagenicity assay or chromosomal aberration assay in Chinese hamster ovary cells.

Plasma glucose concentrations were significantly reduced with Byetta compared with placebo Figure 3. If pancreatitis is suspected, Byetta should promptly be discontinued and appropriate management should be initiated.

Caution should be exercised when Byetta is administered to a nursing woman. The pain may be felt going from your abdomen through to your back. Set up your new pen just before you use it the first time. Postmarketing reports of serious hypersensitivity reactions eg anaphylaxis and angioedema. Support Center Support Center. The most frequently reported adverse reactions leading to withdrawal for Byetta-treated patients were nausea 5. The Double B logo is a trademark of the AstraZeneca group of companies.

C Risk not ruled out. Population pharmacokinetic analysis of patients ranging from 22 to 73 years of age suggests that age does not influence the pharmacokinetic properties of exenatide [see Clinical Pharmacology Other antidiabetic therapies should be considered in patients with a history of pancreatitis.

Type 2 Diabetes Medication | BYETTA® (exenatide) injection

Increased risk of hypoglycemia when used in combination with a sulfonylurea SU or when used with p glucose-independent insulin secretagogues eg, meglitinides. Buse et al evaluated exenatide versus sulfonylurea mono-therapy in a multicenter, randomized, triple-blinded, placebo-controlled study 7. It is not known whether Byetta, or other anti-diabetes medications, increase your risk of a heart attack or stroke.

The dose may be administered subcutaneously in the thigh, abdomen, or upper arm. These may be symptoms of pancreatitis. Make sure that the 10 with the line under it is in the center of the dose window. Subscribe byeyta receive email notifications whenever new articles are published. All other trademarks are property of their respective owners.

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Specifically, fetuses from pregnant rabbits given SC doses of 0. In patients taking warfarin, prothrombin time should be byteta more frequently after initiation or alteration of Byetta therapy. Read this Medication Guide and the Pen User Manual that come with Byetta before you start using it and each time you get a refill.

Views Read Edit View history. Effects of exenatide exendin-4 on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea.

Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

In Combination with a Sulfonylurea 30 Weeks. Please review our privacy policy. This insulin secretion subsides as blood glucose concentrations decrease and approach euglycemia.

In developmental toxicity studies, pregnant animals received exenatide subcutaneously during organogenesis. Byetta is not a substitute for insulin. The Journal of Biological Chemistry.

Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

In Combination with Metformin 30 Weeks. Byetta slows gastric emptying, thereby reducing the rate at which meal-derived glucose appears in the circulation. See Table 9 for insulin dose titration algorithm.

Write your bjetta here After initiation and dose increases of BYETTA, observe patients carefully for pancreatitis including persistent severe abdominal pain, sometimes radiating to the back, with or without vomiting.