Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. Previous studies have demonstrated that the ability of A. The present study aimed to investigate the potential of salt stress to enhance the accumulation of the anticancer phytochemicals in Andrographis paniculata accessions. Therefore, in the present study, an attempt was made to investigate the anticancer potential of hydroalcoholic extracts of A. The comparison of decrease panicylata studied morphological traits in tolerant and sensitive accessions of A.

View at Google Scholar K. Further studies are required to isolate the active constituents involved in the antioxidant and hepatoprotective activity of the plant. There are several commercially available HDAC inhibitors but they are highly toxic in nature. Experimental studies on prevention of atherosclerotic arterial stenosis and restenosis after angioplasty activify Andrographis paniculata nees and fish oil.

It is assumed that the accumulation of these phytochemicals in A. In this regard, our results indicated that proline as well as the AG and NAG contents is positively correlated with the substrate concentration of salt, in which the tolerant accessions were higher in proline, AG, and NAG contents compared with the sensitive ones.

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This finding matched up with the Chutipaijit et al. The experiment was carried out with a split plot based on a randomized complete block design RCBD with two factors and three replicates. Accession showed a growth reduction of dry weight up to The slight differences in retention times RT of the phytochemicals are due to the running of the samples in different batches using a refreshed mobile phase.

Five human cancer cell lines i. For this purpose, day-old plants were grown in different salinity levels 0. The plant extract contains three major groups of phytochemical compounds, namely, diterpenes, flavonoids and stigmasterols [ 16 ].

Phytochemical study showed the presence of flavonoids, tannins, carbohydrate, cardiac glycosides, terpenes and steroids in both the plant extracts. Reportedly, improving the pqniculata of some phytochemicals such as flavonoids as one of the most important pharmaceutical contents could be enhanced through salinity and drought stresses [ 121415 ]. Therefore, the aim of this study was to determine the changes in the contents of the three main anticancer phytochemicals AG, NAG, and DDAG and their physiological implications in salt tolerance of A.

The dried materials were chopped into small pieces and ground into fine powder form and were then extracted with a mixture of aftivity and methanol DCM: Chemotherapy is a major clinical treatment used for the control of advanced stages of malignancies and metastasis. After inducing a period of day salinity stress and before flowering, all plants were harvested and the data on morphological traits, proline content and the three anticancer phytochemicals, including andrographolide AGneoandrographolide NAGand deoxy,didehydroandrographolide DDAGwere measured.


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The extracts were then stored below ambient temperature for further studies. Van Der Hejden, H.

Recent studies have reported antitumor effects of the flavonoids, quercetin, genistein and baicalein obtained from plant extracts Shoeb et al. PDF Kb Abstract Plant-derived compounds act as a prevention within the development of many anti-cancer agents.

So now a days they are widely used for curing many diseases including cancer. In the current study, phytochemical analysis was conducted on the four different accessions of A. By this time, the tolerant accession also had significantly higher proline and phytochemical contents and less leaf necrosis than sensitive accession Salinity is a major abiotic stress that causes important alterations in the plant growth and development.

Pzniculata materials were soaked for three days at room temperature.

Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

Thus, consuming a diet rich in antioxidant plant material can provide health-protective effects. Variations due to salinity levels SL and accessions AC were highly significant. Apart from this, alkaloids were present only in the extract of Andrographis paniculata while, saponins were present only in Silybum marianum extract Table 1.

The relative amounts of phytochemicals in salt-tolerant a and salt-sensitive b accessions of A. Introduction Salinity is a major abiotic stress that causes important alterations in the plant growth and development.