Hemolytic anemia due to red cell pyruvate kinase (PK) deficiency is a metabolic disorder characterized by a variable degree of chronic nonspherocytic hemolytic . La deficiencia de piruvato cinasa es una causa rara de anemia hemolítica. Durante el embarazo, se ha tratado casos graves de esta deficiencia con. Anemia Hemolítica no esferocítica (AHCNE) por deficiencia de piruvato quinasa: informe del segundo caso en Costa Rica. Rev. costarric. cienc. méd [online].

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For yet unexplained reasons, all PK-deficient dogs develop a progressive myelofibrosis and then osteosclerosis, as seen in this case, though PK-deficient cats and humans do not experience osteoclerosis. While PK-deficient cats and humans may also develop bilirubin calculi and gall bladder blockade, deficiencis has not been reported in PK-deficient dogs. Consultations of Feline Med Surg.

PK deficiency is a hereditary disorder which has been studied by hematologists and geneticists for decades, in an attempt to better understand its disease process and prevalence, and in order to reach more reliable diagnosis and develop better therapeutics for affected patients.

Indeed, dogs can become sensitized to other RBC antigens than one can test for and thus be incompatible to even the “universal donor” Callan et alBlais et alKessler et al Dogs with Cihasa deficiency often have normal white blood cell counts. No clinically practical specific treatment has yet been established for PK-deficient animals.

Thus, alloantibodies against DEA 1. It should be noted that the fall in PCV observed in the last month of life was associated with a diminished bone marrow response, as shown by both the lower absolute reticulocyte count and reticulocyte production index.


Mol Med 16, Nevertheless, a transfusion was deemed so desperately needed that blood from a “universal donor” was given. The dog had been previously transfused without blood typing and crossmatching.

Permission to perform a necropsy was not received. While dogs do not generally have any clinically relevant naturally occurring alloantibodies, they can develop antibodies against blood groups and a common red cell antigen following transfusion, as seen in this case.

Arch Med Vet 44, While the patient was undergoing treatment, there was apparently slight clinical improvement, but hematological parameters never returned to normal range Weiden et alGiger and NobleGiger Health care resources for this disease Expert centres Diagnostic tests 40 Patient organisations 39 Orphan drug s 1.

Some clinical improvement was observed within a day, but the PCV did not rise. In previous clinical visits babesiosis was suspect due to severe anemia and also giardiasis because the puppy had some episodes of loose and greennish faeces. Are currently enrolled in another therapeutic clinical trial involving ongoing therapy with any investigational or marketed product or placebo.

Hemolytic transfusion reactions in a dog with an alloantibody to a common antigen. For all the other canine breeds, detailed enzymatic activity tests that include the characterization of the isoenzymes or heat-lability are necessary.


The degree of osteosclerosis was radiographically mild, but the marrow was not histopathologically examined. Indeed, this likely explains why most PK-deficient dogs can cope so well, despite a persistently severe anemia Chapman and GigerGiger and NobleGiger In dogs, PK deficiency causes a severe chronic and highly regenerative hemolytic anemia with progressive osteosclerosis, while in cats it is characterized by an intermittent hemolytic anemia without osteosclerosis.

It should be noted that cinzsa fall in PCV observed in the last month deiciencia life was drficiencia with a diminished bone marrow response, as shown by both the lower absolute reticulocyte count and reticulocyte production index.


Historically the puppy was weak, has episodes of syncope and constantly showed pale gums on routine clinical examination. The high erythrocytic content of 2,3-DPG facilitates the easy release of oxygen from hemoglobin by the lower hemoglobin-oxygen affinity, which in turn improves oxygen delivery and enhances tissue oxygenation, thereby ameliorating the clinical signs of the severe anemia.

Because PK piruato causes a distal metabolic block in the anaerobic glycolytic pathway, the proximal glycolytic metabolites, including 2,3-diphosphoglycerate 2,3-DPGtend hemlitica accumulate, while distal metabolites like ATP become depleted in erythrocytes.

Hereditary red cell defects are important differential diagnoses for chronic hemolytic anemias in younger animals after excluding immune-mediated and infectious causes. Have a prior bone marrow or stem cell transplant 8.

Piruvato quinase

Haber recibido tratamiento previo con un activador de PK 7. Permission to perform a necropsy was not received. Regenerative anemias caused by blood loss or hemolysis. Clinically, PK-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.

Hum Mol Genet 19, Unstable extramedullary hematopoiesis that deficiencia de piruvato cinasa pose a risk of imminent neurologic compromise o. Many animals with hemolytic anemia are initially misdiagnosed and treated for infectious diseases e.

Pyruvate kinase deficiency causing hemolytic anemia with secondary hemo-chromatosis in Cairn terrier.